Clinical Research Directory

Inclusion Criteria: * Participant must be 40 to 60 years of age inclusive, at the time of signing the informed consent. * Male or female. * Participants who are healthy as determined by medical evaluation including medical history and physical examination. * Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the study protocol. * Self-reported normal sleep patterns, assessed by Pittsburgh sleep quality index (PSQI; cutoff ≤ 5). * No current use of sleep medications or supplements. * Able to wear polysomnographic equipment and actigraphy during nighttime. Exclusion Criteria: * History of sleep disorders (e.g. insomnia, sleep apnea). * Abnormal findings on PSG, such as sleep related breathing disorders (apnea-hypopnea index (AHI) ≥ 5), sleep related movement disorders (periodic limb movement index (PLMI) ≥ 15, and parasomnias (like REM sleep behavior disorder (RBD)). * Chronic use of alcohol, tobacco, or medications affecting sleep. * Significant psychiatric or medical conditions (including neurological, heart, lung, or sleep disorders/diseases). * Travelled \>1 time zone and night work \<1 month before study, or during the study. * Extreme chronotype according to the Composite Morningness Questionnaire (evening type; \<22 and morning type \>44). * Pregnancy. * Breastfeeding. * Supplements resulting in \> 20 mg daily of nicotinamide riboside, nicotinamide mononucleotide (NMN), niacin (vitamin B3, nicotinic acid amide or other vitamin B3 analogues) less than 3 months prior to randomization. * Participation in other clinical trials last 3 months. * Deemed ineligible by lead principal investigator.