Clinical Research Directory

Inclusion Criteria: 1. Aged 18-65 years 2. Traumatic or non-traumatic SCI, \> 6 months since SCI onset Motor incomplete SCI (American Spinal Injury Association Impairment Scale, AIS C and D), neurologic level of injury (NLI) between C1-L2 (inclusive), as determined by the International Standards for Neurological Classification of SCI (ISNCSCI) 3. Able to walk with or without walking aid independently for at least 2 meters 4. No current or history of other neurological conditions 5. Community-dwelling or living in a rehabilitation facility 6. Medically stable for full weight-bearing locomotor training including 15-minute standing frame trial to assess standing tolerance 7. Weigh 220 pounds (100 kg) or less (exoskeleton equipment requirement) 8. Between approximately 1.5 m and 1.9 m (5'0" and 6'4") tall (exoskeleton equipment requirement) 9. Standing hip width of approximately 45 cm (18") or less (exoskeleton equipment requirement) 10. Sufficient range of motion (ROM) to achieve a normal, reciprocal gait pattern, and normal sit-to-stand transitions. Hip extension greater than or equal to 5-degree Knee extension greater than or equal to 5-degree Ankle dorsiflexion greater than or equal to 0-degree 11. Sufficient upper extremity strength to use a front wheeled walker by manual muscle testing (minimum triceps strength bilaterally of 3/5 of Oxford Scale, shoulder abduction and flexion/extension 4/5 of Oxford Scale) Exclusion Criteria: 1. AIS-A SCI or AIS-B SCI 2. Have been trained in exoskeleton or other robotic device for locomotor training within the past 4 months except for one or two training/demonstration sessions 3. Currently involved in another intervention study 4. Any medical issue that precludes full weight-bearing locomotor training including but not limited to: Spinal instability (or spinal orthotic unless cleared by physician) Acute deep vein thrombosis (DVT) with activity restrictions Severe, recurrent autonomic dysreflexia (AD) requiring medical intervention Heterotopic ossification (HO) in the lower extremities resulting in ROM restrictions at the hips or knees Two or more pathological fractures in the last 48 months in a major weight-bearing bone (femur or tibia) in the lower extremity Hip subluxation (x-rays will be obtained for individuals injured prior to 10 years of age) 5. Any medical issue that would affect participant safety either due to cognitive deficits/impulsivity, intolerance to mild exercise, or other factors 6. Any issue that would confound results such as a concurrent neurological injury or disorder (other than SCI) or other factors 7. Skin integrity issues in areas that contact the device (including abdominal ostomies) or that would prohibit sitting 8. Pregnancy 9. Participants who do not meet the exoskeleton equipment requirements 10. Modified Ashworth Scale (MAS) = 4 in the majority of lower extremity joints (e.g. greater than or equal to four joint movements in bilateral lower extremities when testing hip flexion/extension, knee flexion/extension, ankle dorsi/plantar flexion)