Clinical Research Directory

Inclusion Criteria: 1. Implanted on-label with NMP in at least one vertebral level in the cervical (C1-C7) or lumbar (L1-S1) spine as part of their surgery 2. Total volume of bone graft or bone graft substitute used in index surgery must contain at least 50% NMP by volume per treated level, where NMP is mixed with other graft material. 3. Skeletally mature (age≥18 years of age) 4. Be willing to sign the study-specific informed consent document prior to index surgery Exclusion Criteria: 1. Not willing to sign the study-specific informed consent document prior to index surgery 2. Use of allogenic growth factor extacts (i.e. OsteoFactor/ProteiOS) or cell based allografts as part of the index surgery (use of autograft or bone marrow aspirate (BMA) is allowed) 3. Use of rhBMP-2 (i.e. INFUSE) or synthetic peptide enhanced graft (i.e. iFactor) as part of the index surgery 4. Diagnosis of spinal deformity (greater than 20 degrees) or vertebral fracture including treated level 5. Unable to comply with postoperative standard of care imaging (e.g. pregnant or nursing female) 6. Did not complete baseline patient reported outcomes prior to index surgery 7. Incarcerated at the time of surgery or preoperative evaluation