Clinical Research Directory

Inclusion Criteria: 1. Infants born through meconium-stained amniotic fluid, and 2. Gestational age at or greater than 35+0 weeks at birth, and 3. Postnatal age of 10 to 14 days-old, and 4. Full enteral feeds either at semi-demand with a mix of gavage or oral feeds or at full-demand feeds by oral method, and 5. Stable respiratory condition for 24-48 hours prior to enrolment, and require respiratory support defined as: receiving non-invasive respiratory support including one of the following 1. High flow nasal cannula of less than or equal to 2L/min/Kg and FiO2 \<0.25, or 2. Low flow nasal cannula at \<100 ml/min Exclusion Criteria: 1. Preterm infants of less than 35+0 weeks gestation, or 2. Postnatal age younger than 9 day-old or older than 15 day-old, or 3. Parenteral nutrition supplementation or full enteral feeds by gavage, or 4. Received caffeine within 5 days prior to enrolment, or 5. Currently, receiving invasive respiratory support or continuous positive airway pressure (CPAP), or 6. During the study period with the administration of study medication, the infant cannot receive steroids including dexamethasone, hydrocortisone and budesonide by intravenous, enteral or inhalational route, or 7. Medical diseases including infections, electrolytes or acid-base imbalances, significant anemia, systematic and metabolic disorders that contribute to respiratory insufficiency other than meconium aspiration syndrome, or 8. Congenital anomalies including but not limited to respiratory tract malformations, congenital heart diseases, and syndromal abnormalities.