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Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Sponsor: Centre Hospitalier Universitaire de Nice
Summary
Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death. "
Key Details
Gender
All
Age Range
Any - 143 Days
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2010-01-01
Completion Date
2026-12-30
Last Updated
2026-01-28
Healthy Volunteers
No
Conditions
Interventions
Premature neonates with invasive infection caused by Bacillus cereus
The whole genome sequencing of the bacterial strains was performed by using both Illumina and Nanopore technologies, allowing us to obatin high quality and complete circular genomes.
Locations (13)
CHU NICE
Nice, Alpes Maritimes, France
CHU lille
Lille, France
AP-HM Marseille
Marseille, France
CHU Nantes
Nantes, France
CHU Nîmes
Nîmes, France
AP-HP Hôpital Robert Debré
Paris, France
Hôpital Antoine Béclère, AP-HP
Paris, France
Hôpital Cochin
Paris, France
CHU de Poitiers
Poitiers, France
CHU Rennes
Rennes, France
CHRU de Strasbourg
Strasbourg, France
CHU Toulouse
Toulouse, France
CHU de Tours
Tours, France