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Resilience to Antibiotic-induced Obesogenic Microbiota: Discovering Mechanism of Microbiota Modulation
Sponsor: Turku University Hospital
Summary
The aim is to study whether the microbiota of children who are exposed to antibiotics at birth could be modified by synbiotic supplement and thereby reduce the risk of obesity, chronic diseases and respiratory tract infections. A total of 125 mother-child pairs will be recruited in this randomized, double-blind, placebo-controlled study. Infants are randomized to receive either a synbiotic supplement or a placebo for 2 months, after which their growth and morbidity will be monitored at the research clinic for 2 years.
Official title: Resilience to Antibiotic-induced Obesogenic Microbiota Vertically Transferred to the Neonatal Gut: Discovering Mechanism of Microbiota Modulation
Key Details
Gender
All
Age Range
2 Hours - Any
Study Type
INTERVENTIONAL
Enrollment
125
Start Date
2024-05-08
Completion Date
2029-12
Last Updated
2025-05-16
Healthy Volunteers
No
Conditions
Interventions
Synbiotic Supplement
Bifidobacterium bifidum and human milk oligosaccharides (HMOs)
Placebo
Maltodextrin
Locations (1)
Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku
Turku, Valitse Maakunta., Finland