Clinical Research Directory

Inclusion Criteria: * Patients who meet all of the following criteria are eligible to participate in the study: 1. Aged 18-70 years; 2. No gender restriction; 3. ECOG Performance Status 0-1; 4. Chest CT-confirmed chest wall-originating tumor; 5. Histologically/cytologically confirmed primary or metastatic chest wall tumor; 6. Anticipated intraoperative anterolateral chest wall defect diameter 5-10 cm (maximum) or costal arch reconstruction required (investigator-assessed); 7. Scheduled for prosthetic chest wall reconstruction; 8. No prior chest wall reconstruction surgery; 9. Willing to provide written informed consent and comply with follow-up visits and protocol requirements. Exclusion Criteria: * Patients who meet any of the following criteria are ineligible for this study: 1. Patients with posterior chest wall defects; 2. Uncontrolled underlying medical conditions or contraindications to general anesthesia; 3. Pregnant or lactating women; 4. Concurrent severe comorbidities that may interfere with study evaluations, including: Severe hepatic, cardiac, or renal diseases; Active malignancies (other than the indicated chest wall tumor); Alcohol use disorder 5. lnability to provide reliable symptom reporting due to:P sychiatric disorders, Severe neurosis, Non-compliance with trial requirements 6. Women of childbearing potential\* and their partners unwilling to use effective contraception; 7. Prior history of chest wall reconstruction surgery; 8. Active uncontrolled bacterial, fungal, or viral infections; 9. Participation in other clinical trials within 3 months prior to enrollment; 10. Any other conditions deemedunsuitable by the investigator