Clinical Research Directory

Inclusion Criteria: 1. Aged 18-65 years (including the critical value), regardless of gender; 2. The Con group was diagnosed with type 2 diabetes and had no history of mental disorders such as depression; 3. The T2DD patient group was diagnosed with type 2 diabetes and depression, where depression met the DSM-5 diagnostic criteria for recurrent depression without psychotic symptoms or single-episode MDD, and the total score of the HAMD-17 scale was ≥22 points; 4. The subjects read and fully understood the patient instructions and signed the informed consent form. Exclusion Criteria: 1. Those who do not meet the inclusion criteria; 2. Those who have not used antibiotics, prebiotics, probiotics, enteral nutrition drugs, etc. within 3 months before diagnosis, and those who do not use antibiotics, prebiotics, probiotics, enteral nutrition drugs, etc. during treatment; 3. Those with progressive serious diseases (such as cancer); 4. Those with severe aphasia, agnosia, and apraxia; 5. Those who have used psychotropic drugs for a long time within 1 month before the study or have received new drug research in the past 3 months; 6. Pregnant or breastfeeding women; 7. Alcoholics or drug addicts; 8. Those with poor mental condition and unable to cooperate; 9. Those who are considered unsuitable for inclusion in the study.