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Research for Plasma Biomarkers Associated With Fatigue in Thrombocytopenic Patients
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Thrombocytopenia is a clinical problem defined by a platelet count lower than 150×10⁹/L. It can be linked to various pathologies of central origin, such as decreased platelet production in the bone marrow, or peripheral origin with increased platelet destruction through autoimmune mechanisms, increased splenic sequestration, or excessive platelet consumption. Significant fatigue is often reported in association with thrombocytopenia, but its underlying pathophysiology remains unclear. One hypothesis is the role played by neurotrophic factors contained in platelets and released into the circulation following their activation, in particular the Brain-Derived Neurotrophic Factor (BDNF), which promotes the survival, growth, differentiation, and plasticity of neurons in both the central and peripheral nervous systems. Consequently, BDNF plays a key role in long-term memory, intellectual abilities, and neuroprotection. In this context, this project aims to confirm whether platelet-origin neurotrophic biomarkers could explain the fatigue experienced by thrombocytopenic patients and whether it depends on the etiology of the thrombocytopenia.
Key Details
Gender
All
Age Range
8 Years - Any
Study Type
INTERVENTIONAL
Enrollment
280
Start Date
2025-03-26
Completion Date
2028-06-26
Last Updated
2026-02-03
Healthy Volunteers
Yes
Conditions
Interventions
blood sampling
3 blood tubes will be taken during a standard check-up
self-administrated questionaires
4 self administrated questionaires and scales at the inclusion
Locations (1)
Hôpital Bichat-Claude Bernard
Paris, France