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RECRUITING
NCT06979765
NA

Research for Plasma Biomarkers Associated With Fatigue in Thrombocytopenic Patients

Sponsor: Assistance Publique - Hôpitaux de Paris

View on ClinicalTrials.gov

Summary

Thrombocytopenia is a clinical problem defined by a platelet count lower than 150×10⁹/L. It can be linked to various pathologies of central origin, such as decreased platelet production in the bone marrow, or peripheral origin with increased platelet destruction through autoimmune mechanisms, increased splenic sequestration, or excessive platelet consumption. Significant fatigue is often reported in association with thrombocytopenia, but its underlying pathophysiology remains unclear. One hypothesis is the role played by neurotrophic factors contained in platelets and released into the circulation following their activation, in particular the Brain-Derived Neurotrophic Factor (BDNF), which promotes the survival, growth, differentiation, and plasticity of neurons in both the central and peripheral nervous systems. Consequently, BDNF plays a key role in long-term memory, intellectual abilities, and neuroprotection. In this context, this project aims to confirm whether platelet-origin neurotrophic biomarkers could explain the fatigue experienced by thrombocytopenic patients and whether it depends on the etiology of the thrombocytopenia.

Key Details

Gender

All

Age Range

8 Years - Any

Study Type

INTERVENTIONAL

Enrollment

280

Start Date

2025-03-26

Completion Date

2028-06-26

Last Updated

2026-02-03

Healthy Volunteers

Yes

Conditions

Interventions

BIOLOGICAL

blood sampling

3 blood tubes will be taken during a standard check-up

OTHER

self-administrated questionaires

4 self administrated questionaires and scales at the inclusion

Locations (1)

Hôpital Bichat-Claude Bernard

Paris, France