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Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Esophageal Carcinoma
Sponsor: Xijing Hospital
Summary
The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of serum tumor markers. Secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (PFS), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-05-26
Completion Date
2030-03-01
Last Updated
2025-12-16
Healthy Volunteers
No
Conditions
Interventions
Multi-gene methylation testing
Undergo multi-gene methylation testing in blood during follow-up
Multi-gene methylation testing
Undergo multi-gene methylation testing in blood during follow-up
Multi-gene methylation testing
Undergo multi-gene methylation testing in blood during follow-up
Multi-gene methylation testing
Undergo multi-gene methylation testing in blood during follow-up
Locations (9)
Gansu Wuwei Cancer Hospital
Wuwei, Gansu, China
Cancer Hospital Affiliated to Shantou University Medical College
Shantou, Guangdong, China
Zhaoqing Gaoyao District People's Hospital
Zhaoqing, Guangdong, China
Henan Cancer Hospital
Zhengzhou, Henan, China
Tangdu Hospital
Xi'an, Shaanxi, China
Xijing Hospital
Xi'an, Shaanxi, China
The First Affiliated Hospital of Yan'an University
Yan’an, Shaanxi, China
The First Affiliated Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
General Hospital of Western Theater Command, People's Liberation Army (PLA)
Chengdu, Sichuan, China