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Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Gastric Cancer
Sponsor: Xijing Hospital
Summary
The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of serum tumor markers. Secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (PFS), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2025-05-25
Completion Date
2030-03-01
Last Updated
2025-05-20
Healthy Volunteers
No
Conditions
Interventions
Multi-gene methylation testing
Undergo multi-gene methylation testing in blood during follow-up
Multi-gene methylation testing
Undergo multi-gene methylation testing in blood during follow-up
Locations (2)
Tangdu Hospital
Xi'an, Shaanxi, China
Xijing Hospital
Xi'an, Shaanxi, China