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The PROTECT Trial: PROpofol Titration to Enhance haemodynamiC sTability
Sponsor: University Hospital, Basel, Switzerland
Summary
The aim of this multicentre, single-blinded, expertise-based randomised controlled trial is evaluate whether slowly increasing the dose of the anaesthetic drug propofol based on a patient's needs leads to more stable blood pressure compared to giving a standard starting dose in patients aged 55 and older undergoing non-cardiac surgery.
Official title: Multicentre Single-blinded, Expertise-based RCT Comparing Haemodynamic Parameters Between Titration and Conventional Induction of General Anaesthesia With Target-controlled Infusion System in Patients Undergoing Non-cardiac Surgery
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
320
Start Date
2025-09-02
Completion Date
2027-09
Last Updated
2025-09-19
Healthy Volunteers
No
Conditions
Interventions
Propofol titration
Induction starts with propofol target-controlled Infusion (TCI) (Schnider model) at target effect-site drug concentration (Cet) 0.5-1.0 µg/mL and remifentanil TCI (Minto model) at Cet 0.5 ng/mL. If loss of consciousness (LOC) is not reached, propofol Cet is increased in 0.5-1.0 µg/mL steps. For intubation, remifentanil Cet increases up to 6.0 ng/mL.
Conventional propofol induction
Induction starts with propofol TCI at Cet 4-8 µg/mL and remifentanil TCI at Cet 2.5-3.5 ng/mL.
Locations (4)
Kantonsspital Baden
Baden, Switzerland
University Hospital Basel
Basel, Switzerland
Cantonal Hospital Graubünden
Chur, Switzerland
Kantonsspital Olten, soH
Olten, Switzerland