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ANI-Guided Anesthetic Desflurane Consumption
Sponsor: Wonkwang University Hospital
Summary
General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability. The Analgesia/Nociception Index (ANI), derived from heart rate variability (HRV), quantifies parasympathetic tone to assess nociception-antinociception balance on a 0-100 scale, with lower values indicating nociceptive stress. ANI analyzes high-frequency HRV components, reflecting parasympathetic inhibition during painful stimuli, making it a reliable indicator of intraoperative nociception. Studies validate the utility of ANI in detecting nociceptive events during laparoscopic surgery. ANI-guided opioid titration reduces opioid consumption and stabilizes hemodynamics, enhancing perioperative outcomes.
Official title: Analgesia/Nociception Index (ANI)-Guided Desflurane Titration Reduces Anesthetic Consumption in Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
19 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
125
Start Date
2026-07-02
Completion Date
2026-08-30
Last Updated
2026-07-06
Healthy Volunteers
No
Interventions
Analgesia/Nociception Index (ANI)
ANI was monitored using the ANI monitor (MetroDoloris, France) in both groups, but only guided adjustments in the ANI group
Locations (1)
Wonkwang University School of Medicine Hospital
Iksan, Jeollabuk-do, South Korea