Clinical Research Directory

Inclusion Criteria: 1. Primary Diagnosis of MDD with Anhedonia, established according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM5TR) - HDRS-17 score of ≥20, SHAPS-C score of ≥25. 2. Fluency in written and spoken English. 3. Able intellectually to understand the instructions 4. Ability to give signed, informed consent either written or electronic (via REDCap eConsent). 5. Normal or corrected-to-normal vision and hearing. 6. Ability to adhere to the study schedule. 7. Completed at least one antidepressant treatment course at an adequate dose and duration in the current episode per the ATRQ. Exclusion Criteria: 1. Contraindications to MRI (e.g., metal in the body, claustrophobia). 2. Any suicidal behavior in the past 1 year (i.e., actual attempt, interrupted attempt, aborted attempt, or preparatory acts or behavior) assessed using Columbia -Suicide Severity Rating Scale (C-SSRS) prior to screening and during the screening period. 3. Diagnosis for current moderate or severe substance or alcohol use disorder (SUD/AUD) within the past month (as defined in DSM-5-substance use disorder). 4. Any unstable medical condition, as per the clinical judgement of the investigator. 5. Any change in, or initiation of, fluoxetine within the past 8 weeks or of other SSRIs/SNRIs antidepressants, bupropion, stimulants, or other psychiatric medications within the past 4 weeks. 6. Recent initiation (within the past 2 months) of psychotherapy; continuation of established maintenance supportive therapy will be permitted. 7. Enrollment in another therapeutic clinical study at screening or within 2 months prior to screening or intended enrollment within the duration of this study.