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Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Sponsor: Duke University
Summary
Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain. This research will examine how smoking withdrawal changes the way the brain processes pain, and whether these withdrawal-related changes interfere with the ability to stop smoking. The results of this research will provide important information that can be used to guide the development of interventions to help people with chronic pain who smoke cigarettes to quit smoking and improve their health.
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
132
Start Date
2025-11-04
Completion Date
2030-03-31
Last Updated
2025-11-20
Healthy Volunteers
No
Conditions
Interventions
Smoking as usual fMRI session
Participants in this condition will continue smoking as usual prior to the fMRI session
Abstinent fMRI session
Participants in this condition will be asked to abstain from smoking or using any other tobacco products for 24 hours prior to the fMRI session
Locations (1)
Duke North Pavilion
Durham, North Carolina, United States