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RECRUITING
NCT06983730
EARLY_PHASE1

The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

Sponsor: Beth Israel Deaconess Medical Center

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Official title: Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress

Key Details

Gender

All

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

28

Start Date

2026-01-26

Completion Date

2028-06

Last Updated

2026-02-05

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Vitamin B3

1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.

Locations (2)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Boston University

Boston, Massachusetts, United States