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The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Sponsor: Beth Israel Deaconess Medical Center
Summary
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?
Official title: Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
28
Start Date
2026-01-26
Completion Date
2028-06
Last Updated
2026-02-05
Healthy Volunteers
Yes
Interventions
Vitamin B3
1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.
Locations (2)
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Boston University
Boston, Massachusetts, United States