Clinical Research Directory
Browse clinical research sites, groups, and studies.
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population
Sponsor: Ningbo No. 1 Hospital
Summary
The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.
Official title: Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population: a Cohort Study
Key Details
Gender
All
Age Range
20 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
2720
Start Date
2025-04-01
Completion Date
2025-12-31
Last Updated
2025-06-04
Healthy Volunteers
Not specified
Conditions
Interventions
Observational
Observational
Locations (1)
the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000
Ningbo, Zhejiang, China