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RECRUITING
NCT06985420

The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise

Sponsor: University of Central Florida

View on ClinicalTrials.gov

Summary

The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are: Does the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases. Participants will: Complete resistance exercise protocols across three different menstrual cycle phases. Provide blood samples to assess immune cell activation and muscle damage markers. Track sleep, mood, and recovery with questionnaires and wear an accelerometer.

Official title: The Impact of the Menstrual Cycle on Innate Immune Cell Activation, Recruitment, and Adhesion Dynamics During Recovery From Damaging Resistance Exercise: Role of Neutrophils and Systemic Chemokines.

Key Details

Gender

FEMALE

Age Range

18 Years - 40 Years

Study Type

OBSERVATIONAL

Enrollment

40

Start Date

2024-08-16

Completion Date

2025-05

Last Updated

2025-05-22

Healthy Volunteers

No

Interventions

OTHER

Resistance exercise

Resistance Exercise Protocols: Participants will perform exercises, including belt squats, hex bar deadlifts, and plyometric drop jumps. The load and intensity will be standardized based on each participant's 1-repetition maximum (1RM) to ensure uniformity across trials.

OTHER

Menstrual Cycle Phases

Menstrual Cycle Phases: The key exposure variable is the phase of the menstrual cycle, with participants being assessed during the early follicular, late follicular, and mid-luteal phases.

Locations (1)

University of Central Florida

Orlando, Florida, United States