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ENROLLING BY INVITATION
NCT06987058
PHASE2

RVU120 Rollover Study

Sponsor: Ryvu Therapeutics SA

View on ClinicalTrials.gov

Summary

This is a multicenter rollover study to provide continued treatment to eligible participants previously enrolled in a RVU120 clinical study and to evaluate the safety of the treatment and record the time on treatment when continued under the same regimen as in the parent study. To be eligible for this rollover study, participants must be continuing to benefit from their treatment, show an acceptable safety profile, and not have access to commercially available comparator anticancer therapy. Once transitioned to this study, participants will continue with their next planned dose per the regimen of their parent study.

Official title: An Open-label Multicenter Rollover Study to Provide Continued Treatment to Participants Previously Enrolled in a RVU120 Clinical Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

14

Start Date

2025-12-04

Completion Date

2026-12

Last Updated

2026-09-17

Healthy Volunteers

No

Interventions

DRUG

RVU120

RVU120 is a potent, selective inhibitor of CDK8 and its paralog CDK19

DRUG

Ruxolitinib

Selective inhibitor of the Janus Associated Kinases (JAKs) JAK1 and JAK2

Locations (7)

Hôpital l'Archet 1 - CHU de Nice; Service Hématologie Clinique

Nice, France

Hôpital Haut-Lévêque- CHU de Bordeaux, Centre François Magendie, Service d'Hématologie Clinique et Thérapie Cellulaire

Pessac, France

M2M Med Sp. Z o.o.

Chorzów, Poland

CWBK UCK Ośrodek Badań Klinicznych Wczesnych Faz

Gdansk, Poland

Pratia Hematologia Sp. z o.o. Pratia Onkologia Katowice

Katowice, Poland

SPZOZ Szpital Uniwersytecki w Krakowie

Krakow, Poland

Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Terapii Komórkowych i Chorób Wewnętrznych

Wroclaw, Poland