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A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
Sponsor: Celgene
Summary
The purpose of this study is to evaluate the preliminary safety and determine the RP2D of mezigdomide in combination with elranatamab in participants with relapsed and refractory multiple myeloma (RRMM).
Official title: A Phase 1b/2a, Multicenter, Open-label Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2025-10-07
Completion Date
2027-06-03
Last Updated
2026-02-02
Healthy Volunteers
No
Conditions
Interventions
Elranatamab
Specified dose on specified days
Mezigdomide
Specified dose on specified days
Dexamethasone
Specified dose on specified days
Locations (22)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Yale New Haven Hospital-Smilow Cancer Center
New Haven, Connecticut, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada
Local Institution - 0026
Vancouver, British Columbia, Canada
Local Institution - 0027
Halifax, Nova Scotia, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Local Institution - 0030
Suzhou, Jiangsu, China
Local Institution - 0031
Shanghai, Shanghai Municipality, China
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, Germany
Universitaetsklinikum Heidelberg
Heidelberg, Germany
Evangelismos General Hospital of Athens
Athens, Attikí, Greece
Alexandra General Hospital of Athens
Athens, Attikí, Greece
St. Olavs Hospital
Trondheim, Sør-Trøndelag, Norway
Sykehusapoteket Ull
Oslo, Norway
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
Salamanca, Spain
University College London Hospital
London, England, United Kingdom
Royal Marsden Hospital (Sutton)
London, Sutton, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom