Clinical Research Directory

Inclusion Criteria: * 55-85 years of age * Current diagnostic criteria for stage 3 AD patients (AD-MCI) * Current diagnostic criteria for stage 4 AD patients (mAD) * Able to provide consent to be in the study * Willing and able to participate in study activities * Able to lay supine for 30-45 minutes * Able to walk 20 meters * Willing to not perform additional mind-body practices during the duration of the study * Able to use a wearable electronic device (Smart watch) Exclusion Criteria: * Inability to provide informed consent * Regular use of muscle relaxants or anti-anxiety drugs * Any muscle or skeletal issues that would make it difficult to lie still in the supine position for the 1-hour physical therapy * Craniospinal disorders, e.g., Chiari Malformation. * Spinal injuries, clinically relevant disc herniation, spinal stenosis, spondylolisthesis in the sacral, lumbar, thoracic, or cervical spine, spinal bifida, Recent Spinal Surgery * Severe osteoporosis with a risk of fracture * History of neurological disorders such as stroke (during the last year before study start), mild brain injury within past 6 months, multiple sclerosis, presence of intracranial hemorrhage, hydrocephalus, meningitis, encephalitis, brain tumor (except of asymptomatic meningioma GI) * Serious sleep disorders - narcolepsy * Major or uncontrolled psychiatric illness or major depression. * Any condition requiring the use of medication that acts on the brain such as stimulants, sedatives (hypnotics and benzodiazepines), antipsychotics, and anti-anxiety medications, (we will include patients with stable antidepressant treatment and being on mild anti-seizure medication due to polyneuropathy) * Active infection or uncontrolled significant systemic illnesses * Asthma, chronic obstructive pulmonary disease * Recent hearth attack, Implantable defibrillator, poorly controlled blood pressure cardiac arrhythmia, unstable angina pectoris, or symptomatic congestive heart failure * People at risk of blood clots or deep vein thrombosis (DVT) might want to avoid prolonged sitting in the chair * Obesity over 135 kg (300lb) * Smoking more than 5 cigarettes a day or drinking more than 1 alcoholic beverage a day