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Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
Sponsor: University of Alabama at Birmingham
Summary
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will ingest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine, blood, stool during the dietary and oral dosing portions of the study and also collect breath sample during the oral glycolate test
Official title: Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Formers
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2025-05-27
Completion Date
2031-12-31
Last Updated
2025-05-31
Healthy Volunteers
Yes
Conditions
Interventions
Low-oxalate diet and glycolate dosing
Low-oxalate diet 4 days of fixed eucaloric diet with low oxalate (\<60 mg/day), normal calcium content (600-1000 mg/day)
Oral glycolate dosing
Oral 13C-glycolate dosing (0.5 mg/kg)
Oral 13C- ascorbic acid dosing
Oral 13C- ascorbic acid dosing (0.75 mg/kg)
Locations (2)
United States, Alabama University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Texas South Western Medical Center
Dallas, Texas, United States