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A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Sponsor: Pfizer
Summary
Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.
Official title: A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared With Placebo Both With Background First-Line Chemotherapy in Adult Participants With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
982
Start Date
2025-10-03
Completion Date
2029-12-10
Last Updated
2026-04-08
Healthy Volunteers
No
Interventions
ponsegromab
Double-Blind ponsegromab Treatment
placebo
Double-Blind placebo Treatment
Locations (101)
The Kirklin Clinic of UAB Hospital
Birmingham, Alabama, United States
The University of Alabama at Birmingham
Birmingham, Alabama, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
Bryant, Arkansas, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
Conway, Arkansas, United States
CARTI Cancer Center
Little Rock, Arkansas, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
North Little Rock, Arkansas, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
Pine Bluff, Arkansas, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States
Providence Medical Foundation
Santa Rosa, California, United States
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
Washington D.C., District of Columbia, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Invision, LLC
Honolulu, Hawaii, United States
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Cardiology Associates, Inc
‘Aiea, Hawaii, United States
Hope and Healing Cancer Services
Hinsdale, Illinois, United States
Hope and Healing Cancer Services New Lenox
New Lenox, Illinois, United States
University of Kentucky Research Foundation
Lexington, Kentucky, United States
University of Kentucky Healthcare - Markey Cancer Center
Lexington, Kentucky, United States
University of Kentucky Medical Center
Lexington, Kentucky, United States
University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO)
Lexington, Kentucky, United States
JHU Oncology Central Kit Services
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Oncology Investigational Drug Service (IDS)
Baltimore, Maryland, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States
Renown Health Medical Oncology
Reno, Nevada, United States
Renown Office of Clinical Research
Reno, Nevada, United States
Renown Regional Medical Center
Reno, Nevada, United States
OHSU Center for Health & Healing 1
Portland, Oregon, United States
Oregon Health and Science University
Portland, Oregon, United States
OSHU Center for Health and Healing 2
Portland, Oregon, United States
Houston Methodist Hospital
Houston, Texas, United States
Virginia Mason Medical Center
Seattle, Washington, United States
Shoalhaven District Memorial Hospital
Nowra, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
ICON Cancer Centre - Kurralta Park
Kurralta Park, South Australia, Australia
Icon Cancer Centre Hobart
Hobart, Tasmania, Australia
Western Health-Sunshine & Footscray Hospitals
St Albans, Victoria, Australia
Hospital Santa Rita de Cassia
Vitória, Espírito Santo, Brazil
Oncocentro
Belo Horizonte, Minas Gerais, Brazil
Liga Norte Riograndense Contra o Câncer
Natal, Rio Grande do Norte, Brazil
Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, Brazil
CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Quebec, Canada
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre
Greenfield Park, Quebec, Canada
Jewish General Hospital
Montreal, Quebec, Canada
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
The University of Hong Kong-Shenzhen Hospital
Shenzhen, Guangdong, China
The Second Hospital of Dalian Medical University
Dalian, Liaoning, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
Qilu Hospital of Shandong University
Jinan, Shandong, China
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
The First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
Shanghai General Hospital
Shanghai, China
Tata Memorial Hospital
Mumbai, Maharashtra, India
Venkateshwar Hospital
New Delhi, National Capital Territory of Delhi, India
Rajiv Gandhi Cancer Institute And Research Centre
New Delhi, National Capital Territory of Delhi, India
Chittaranjan National Cancer Institute
Kolkata, West Bengal, India
Rabin Medical Center
Petah Tikva, Central District, Israel
Sheba Medical Center
Ramat Gan, Central District, Israel
Rambam Health Care Campus
Haifa, Heifa, Israel
Shaare Zedek Medical Center
Jerusalem, Jerusalem, Israel
Hadassah Medical Center
Jerusalem, Jerusalem, Israel
Sourasky Medical Center
Tel Aviv, TELL ABĪB, Israel
Aichi Cancer Center Hospital
Nagoya, Aichi-ken, Japan
Chiba cancer center
Chiba, Chiba, Japan
National Cancer Center Hospital East
Kashiwa, Chiba, Japan
Kagawa University Hospital
Kita-gun, Kagawa-ken, Japan
St. Marianna University Hospital
Kawasaki, Kanagawa, Japan
Kanagawa cancer center
Yokohama, Kanagawa, Japan
The University of Osaka Hospital
Suita, Osaka, Japan
Shizuoka Cancer Center
Nagaizumi-cho, Shizuoka, Japan
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan
Wakayama Minami Radiology Clinic
Wakayama-shi Kimiidera 870-2, Wakayama, Japan
Yamaguchi University Hospital
Ube, Yamaguchi, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
Kyushu University Hospital
Fukuoka, Japan
University Hospital,Kyoto Prefectural University of Medicine
Kyoto, Japan
Wakayama Medical University Hospital
Wakayama, Japan
Pan American Center for Oncology Trials, LLC - Dorado Office
Dorado, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office
Mayagüez, Puerto Rico
Pan American Center for Oncology Trials, LLC
Rio Piedras, Puerto Rico
Pan American Center for Oncology Trials, LLC
San Juan, Puerto Rico
Inha University Hospital
Incheon, Incheon-gwangyeoksi [incheon], South Korea
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, South Korea
CHA Bundang Medical Center, CHA University
Seongnam-si, Kyǒnggi-do, South Korea
Asan Medical Center
Seoul, Seoul Teukbyeolsi, South Korea
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Samsung Medical Center
Seoul, Seoul-teukbyeolsi [seoul], South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea
Keimyung University Dongsan Hospital
Daegu, Taegu-kwangyǒkshi, South Korea
Inje University Haeundae Paik Hospital
Busan, South Korea
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan