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Phase 2 Study of ADX-038 in Participants With Geographic Atrophy
Sponsor: ADARx Pharmaceuticals, Inc.
Summary
Phase 2 study is designed to assess the efficacy of ADX-038 compared with placebo in participants with GA secondary to AMD. Safety, pharmacokinetics (PK), and pharmacodynamics (PD) will also be assessed.
Official title: A Phase 2, Randomized, Masked, Placebo-Controlled Study of Subcutaneously Administered ADX-038 in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2025-11-10
Completion Date
2030-08-30
Last Updated
2026-09-03
Healthy Volunteers
No
Interventions
ADX-038
siRNA duplex oligonucleotide
Placebo
Saline
Locations (83)
ADARx Clinical Site
Gilbert, Arizona, United States
ADARx Clinical Site
Phoenix, Arizona, United States
ADARx Clinical Site
Bakersfield, California, United States
ADARx Clinical Site
Beverly Hills, California, United States
ADARx Clinical Site
Huntington Beach, California, United States
ADARx Clinical Site
Poway, California, United States
ADARx Clinical Site
Riverside, California, United States
ADARx Clinical Site
Walnut Creek, California, United States
ADARx Clinical Site
Orlando, Florida, United States
ADARx Clinical Site
Wildwood, Florida, United States
ADARx Clinical Site
Hagerstown, Maryland, United States
ADARx Clinical Site
Reno, Nevada, United States
ADARx Clinical Site
Erie, Pennsylvania, United States
ADARx Clinical Site
Austin, Texas, United States
ADARx Clinical Site
Bellaire, Texas, United States
ADARx Clinical Site
Dallas, Texas, United States
ADARx Clinical Site
McAllen, Texas, United States
ADARx Clinical Site
Round Rock, Texas, United States
ADARx Clinical Site
San Antonio, Texas, United States
ADARx Clinical Site
The Woodlands, Texas, United States
ADARx Clinical Site
St. George, Utah, United States
ADARx Clinical Site
Albury, New South Wales, Australia
ADARx Clinical Site
Hurstville, New South Wales, Australia
ADARx Clinical Site
Parramatta, New South Wales, Australia
ADARx Clinical Site
Sutherland, New South Wales, Australia
ADARx Clinical Site
Sydney, New South Wales, Australia
ADARx Clinical Site
East Melbourne, Victoria, Australia
ADARx Clinical Site
Rowville, Victoria, Australia
ADARx Clinical Site
Malvern, Australia
ADARx Clinical Site
Sydney, Australia
ADARx Clinical Site
Graz, Styria, Austria
ADARx Clinical Site
Innsbruck, Tyrol, Austria
ADARx Clinical Site
Vienna, Austria
ADARx Clinical Site
Vienna, Austria
ADARx Clinical Site
Edmonton, Alberta, Canada
ADARx Clinical Site
Vancouver, British Columbia, Canada
ADARx Clinical Site
Vancouver, British Columbia, Canada
ADARx Clinical Site
London, Ontario, Canada
ADARx Clinical Site
Ottawa, Ontario, Canada
ADARx Clinical Site
Ottawa, Ontario, Canada
ADARx Clinical Site
Toronto, Ontario, Canada
ADARx Clinical Site
Toronto, Ontario, Canada
ADARx Clinical Site
Prague, Czechia
ADARx Clinical Site
Prague, Czechia
ADARx Clinical Site
Praha Klanovice, Czechia
ADARx Clinical Site
Bonn, North Rhine-Westphalia, Germany
ADARx Clinical Site
Sulzbach, Saarland, Germany
ADARx Clinical Site
Cologne, Germany
ADARx Clinical Site
Giessen, Germany
ADARx Clinical Site
Mainz, Germany
ADARx Clinical Site
München, Germany
ADARx Clinical Site
Münster, Germany
ADARx Clinical Site
Tübingen, Germany
ADARx Clinical Site
Pécs, Baranya, Hungary
ADARx Clinical Site
Budapest, Hungary
ADARx Clinical Site
Budapest, Hungary
ADARx Clinical Site
Budapest, Hungary
ADARx Clinical Site
Debrecen, Hungary
ADARx Clinical Site
Milan, MI, Italy
ADARx Clinical Site
Roma, RM, Italy
ADARx Clinical Site
Milan, Italy
ADARx Clinical Site
Milan, Italy
ADARx Clinical Site
Milan, Italy
ADARx Clinical Site
Novara, Italy
ADARx Clinical Site
Padova, Italy
ADARx Clinical Site
Coimbra, Portugal
ADARx Clinical Site
Coimbra, Portugal
ADARx Clinical Site
Coimbra, Portugal
ADARx Clinical Site
Porto, Portugal
ADARx Clinical Site
Barcelona, Spain
ADARx Clinical Site
Barcelona, Spain
ADARx Clinical Site
Barcelona, Spain
ADARx Clinical Site
Madrid, Spain
ADARx Clinical Site
Valencia, Spain
ADARx Clinical Site
Olten, Canton of Solothurn, Switzerland
ADARx Clinical Site
Basel, Switzerland
ADARx Clinical Site
Bern, Switzerland
ADARx Clinical Site
Liverpool, BC, United Kingdom
ADARx Clinical Site
Dorchester, Dorset, United Kingdom
ADARx Clinical Site
Wolverhampton, West Midlands, United Kingdom
ADARx Clinical Site
London, United Kingdom
ADARx Clinical Site
London, United Kingdom
ADARx Clinical Site
Sunderland, United Kingdom