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Effect of EIT-guided PEEP in ARDS Patients
Sponsor: Southeast University, China
Summary
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in ARDS patients.
Official title: Effect of EIT-guided PEEP On Clinical Outcomes in ARDS Patients: a Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
19 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
2400
Start Date
2026-03-13
Completion Date
2030-02-20
Last Updated
2026-07-10
Healthy Volunteers
No
Interventions
EIT-guided PEEP
PEEP titrated by EIT will be performed with a decremental trial at the enrollment. Right after completing RM, PEEP will be set to 20cmH2O or to 24cmH2O and then reduced in steps of 2cmH2O from 20 to 4 every 30s.
Locations (17)
Second Hospital of Anhui Medical University
Hefei, Anhui, China
Department of Critical Care Medicine, Zhongshan Hospital of Fudan University
Shanghai, China Mainland, China
Department of Critical Care Medicine, Renji Hospital
Shanghai, China Mainland, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Zhengzhou, Henan, China
The Affiliated Hospital of Hangzhou Normal University
Hangzhou, Jiangsu, China
Zhongda Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Qinghai University Affiliated Hospital
Xining, Qinghai, China
First Affiliated Hospital of Xi'an Jiaotong University
Xian, Shanxi, China
People's Hospital of Quzhou
Quzhou, Zhejiang, China
Affiliated Beijing Chaoyang Hospital of Capital Medical University
Beijing, China
Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine
Hangzhou, China
Ruijin Hospital Shanghai Jiaotong University School Of Medicine
Shanghai, China
Asan Medical Center
Seoul, South Korea
Taichung Veterans General Hospital
Taichung, Taiwan