Clinical Research Directory
Browse clinical research sites, groups, and studies.
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Sponsor: Corxel Pharmaceuticals
Summary
The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin Scale score when compared with placebo following AIS. 2. Risk of symptomatic intracranial hemorrhage of JX10 in participants with AIS. During Part 1, participants will be randomized to JX 10 (1mg/kg, 3 mg/kg) or placebo. During Part 2, participants will receive JX10 (optimal dose chosen from Part 1) or placebo.
Official title: Optimizing Reperfusion to Improve Outcomes and Neurologic Function (ORION): A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group, Phase 2/3 Study to Evaluate the Efficacy and Safety of JX10 in Acute Ischemic Stroke With Late Presentations
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
740
Start Date
2025-05-15
Completion Date
2029-12-31
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
JX10
JX10 is a thrombolytic agent.
Placebo
Placebo is being used as the comparator.
Locations (83)
Corxel Investigational Site
Long Beach, California, United States
Corxel Investigational Site
Sacramento, California, United States
Corxel Investigational Site
Colorado Springs, Colorado, United States
Corxel Investigational Site
Washington D.C., District of Columbia, United States
Corxel Investigational Site
Delray Beach, Florida, United States
Corxel Investigational Site
Chicago, Illinois, United States
Corxel Investigational Site
Wichita, Kansas, United States
Corxel Investigational Site
Baltimore, Maryland, United States
Corxel Investigational Site
Kalamazoo, Michigan, United States
Corxel Investigational Site
Traverse City, Michigan, United States
Corxel Investigational Site
St Louis, Missouri, United States
Corxel Investigational Site
Great Neck, New York, United States
Corxel Investigational Site
New York, New York, United States
Corxel Investigational Site
Toledo, Ohio, United States
Corxel Investigational Site
Tulsa, Oklahoma, United States
Corxel Investigational Site
Dallas, Texas, United States
Corxel Investigational Site
Houston, Texas, United States
Corxel Investigational Site
Ghent, Belgium
Corxel Investigational Site
Blagoevgrad, Bulgaria
Corxel Investigational Site
Burgas, Bulgaria
Corxel Investigational Site
Pleven, Bulgaria
Corxel Investigational Site
Plovdiv, Bulgaria
Corxel Investigational Site
Sofia, Bulgaria
Corxel Investigational Site
Edmonton, Canada
Corxel Investigational Site
Kingston, Canada
Corxel Investigational Site
Baotou, China
Corxel Investigational Site
Beijing, China
Corxel Investigational Site
Beijing, China
Corxel Investigational Site
Changchun, China
Corxel Investigational Site
Guangzhou, China
Corxel Investigational Site,
Harbin, China
Corxel Investigational Site
Harbin, China
Corxel Investigational Site
Kaili, China
Corxel Investigational Site
Linfen, China
Corxel Investigational Site
Shanghai, China
Corxel Investigational Site
Shenyang, China
Corxel Investigational Site
Suzhou, China
Corxel Investigational Site
Weifang, China
Corxel Investigational Site
Xuzhou, China
Corxel Investigational site
Lille, France
Corxel Investigational site
Paris, France
Corxel Investigational Site
Altenburg, Germany
Corxel Investigational Site
Leipzig, Germany
Corxel Investigational Site
Lübeck, Germany
Corxel Investigational Site
Trier, Germany
Corxel Investigational Site
Athens, Greece
Corxel Investigational Site
Chaïdári, Greece
Corxel Investigational Site
Pátrai, Greece
Corxel Investigational Site
Thessaloniki, Greece
Corxel Investigational Site
Pavia, Italy
Corxel Investigational Site
Roma, Italy
Corxel Investigational Site
Fukuoka, Japan
Corxel Investigational Site
Hyōgo, Japan
Corxel Investigational site
Ibaraki, Japan
Corxel Investigational Site
Kamakura, Japan
Corxel Investigational Site
Meguro City, Japan
Corxel Investigational Site
Mitaka, Japan
Corxel Investigational Site
Miyagi, Japan
Corxel Investigational site
Toyota, Japan
Corxel Investigational Site
Yamagata, Japan
Corxel Investigational Site
Yamaguchi, Japan
Corxel Investigational Site
Daugavpils, Latvia
Corxel Investigational Site
Riga, Latvia
Corxel Investigational Site
Kaunas, Lithuania
Corxel Investigational Site
Vilnius, Lithuania
Corxel Investigational Site
Kuching, Malaysia
Corxel Investigational Site
Braga, Portugal
Corxel Investigational Site
Loures, Portugal
Corxel Investigational Site
Belgrade, Serbia
Corxel Investigational Site
Kragujevac, Serbia
Corxel Investigational Site
Niš, Serbia
Corxel Investigational Site
Novi Sad, Serbia
Corxel Investigational Site
Seoul, South Korea
Corxel Investigational Site
A Coruña, Spain
Corxel Investigational Site
Albacete, Spain
Corxel Investigational Site
Barcelona, Spain
Corxel Investigational Site
Girona, Spain
Corxel Investigational Site
Madrid, Spain
Corxel Investigational Site
Málaga, Spain
Corxel Investigational Site
Seville, Spain
Corxel Investigational Site
Valencia, Spain
Corxel Investigational Site
Bangkok, Thailand
Corxel Investigational Site
Khon Kaen, Thailand