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Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
Sponsor: University of Maryland, Baltimore
Summary
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to assess changes in corneal biomechanics following intraocular pressure (IOP)-lowering treatment. The goal is to determine whether Brillouin-derived biomechanical measurements can serve as biomarkers for glaucoma risk and progression.
Official title: Development of Robust Corneal Biomechanical Biomarkers for Glaucoma Using Brillouin Microscopy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2025-09-01
Completion Date
2026-06
Last Updated
2025-09-09
Healthy Volunteers
Yes
Conditions
Interventions
Prostaglandin Analogue -Containing IOP-Lowering Therapy
Subjects with glaucoma may be prescribed prostaglandin analogs as part of their clinical care. This group will be observed longitudinally to assess changes in corneal biomechanics.
Beta Blocker
Subjects with glaucoma may be prescribed topical beta blockers as part of their clinical care. This group will be observed longitudinally to assess changes in corneal biomechanics.
Brillouin Microscopy
Brillouin microscopy is a non-contact optical imaging method used to assess the biomechanical properties of the cornea in vivo with three-dimensional resolution. It will be used to evaluate corneal stiffness in all study subjects.
Locations (1)
University of Maryland School of Medicine
Baltimore, Maryland, United States