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Glofitamab in Real Life
Sponsor: The Lymphoma Academic Research Organisation
Summary
To date, more than 300 patients have been treated with Glofitamab in the Expanded Access Programme (EAP) in France. In this study, it is proposed to perform a retrospective analysis of some of these patients. The aim is to describe the efficacy and safety of Glofitamab in the largest reported real-world cohort, with an expected median follow-up of more than 9 months. Particular focus will be given to the relapsed or refractory chimeric antigen receptors-T (CAR-T) population to confirm the response rates (CRR: 35-39%) of Glofitamab in this population and to assess the optimal timing of therapy initiation \[8, 15\].
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2025-12-01
Completion Date
2026-07-30
Last Updated
2026-01-14
Healthy Volunteers
No
Conditions
Interventions
Glofitamab
Glofitamab received for DLBCL in Early Phase Access
Locations (30)
CH Victor Dupouy
Argenteuil, France
CH d'Avignon - Hôpital Henri Dufaut
Avignon, France
CH de la Côte Basque
Bayonne, France
CHRU Besançon - Hôpital Minjoz
Besançon, France
Hopital D'Instruction Des Armees Percy
Clamart, France
Hopital Henri Mondor
Créteil, France
CHU de Dijon - Hôpital le Bocage
Dijon, France
CH de Dunkerque
Dunkirk, France
CHU de Grenoble - Hôpital Albert Michallon
La Tronche, France
Hôpital de Libourne
Libourne, France
CHRU de LILLE - Claude Huriez
Lille, France
Hopital Saint Vincent-de-Paul
Lille, France
Centre Léon Bérard
Lyon, France
INSTITUT PAOLI CALMETTES - Service Hématologie
Marseille, France
Clinique du Pont de Chaume
Montauban, France
CH de Mulhouse Sud Alsace
Mulhouse, France
CHR d'Orléans
Orléans, France
Hopital Saint-Louis
Paris, France
Chu de Bordeaux - Hopital Haut-Leveque
Pessac, France
CHU Lyon Sud
Pierre-Bénite, France
CHU de Poitiers - Hôpital de La Milétrie
Poitiers, France
CH de Quimper Cornouaille
Quimper, France
CHU de Rennes - Hôpital de Pontchaillou
Rennes, France
Institut Curie - Site Saint-Cloud
Saint-Cloud, France
CHU de Strasbourg
Strasbourg, France
Institut Universitaire du Cancer de Toulouse - Oncopole
Toulouse, France
Chu Bretonneau
Tours, France
CHRU de Nancy - Hôpital de Brabois
Vandœuvre-lès-Nancy, France
Ch de Bretagne Atlantique
Vannes, France
Gustave Roussy Cancer Campus Grand Paris
Villejuif, France