Clinical Research Directory

Inclusion Criteria: * Age from 35 to 85 years. * Subject with x ray imaging evidence of knee OA as Kellgren Lawrence grade = 2 or 3 within 1 month at screening. * Subject diagnosed with mild to moderate knee OA, particularly in patients who failed to respond adequately to conservative nonpharmacologic therapies or analgesics. * Subject with a 100 mm VAS resting pain score ≥ 30 mm in the studied knee at both the screening and treatment visit (screening visit and treatment visit can be on the same day) * Able and willing to comply with all study visits and procedures. * Willin g and capable of providing written informed consent. Exclusion Criteria: * Subjects with known hypersensitivity to hyaluronate. * Subjects with infections or skin diseases in the area of the injection site. * Pregnancy or breast feeding woman. * Joining other interventional trial s within 3 months prior to injecting this study product * Subject receive an intra articular (IA) injection of Hyaluronic Acid (HA) and/or steroid in target knee within 6 months prior to the trial * Subjects with rheumatoid arthritis * Any surgery to the target knee within the 12 months prior to the trial, or surgery to the contralateral knee or other weight bearing joint if it will interfere with knee assessments