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Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73
Sponsor: First Affiliated Hospital of Fujian Medical University
Summary
As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human volunteers. Furthermover, we conducted a comparative analysis of 68Ga-dPNE and 18F-FDG imaging to assess both the radiation dosimetry and diagnostic efficacy of 68Ga-dPNE.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-03-01
Completion Date
2026-03-01
Last Updated
2025-05-30
Healthy Volunteers
Yes
Conditions
Interventions
68Ga-dPNE
Intravenous injection of 68Ga-dPNE. 68Ga-dPNE PET/CT will be used to detect tumors.
18F-FDG
Intravenous injection of 18F-FDG.18F-FDG PET/CT will be used to detect tumors.
Locations (1)
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China