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Identification of the Mechanism of Non-histaminergic Itch Inducing Epigenetic Changes
Sponsor: Aalborg University
Summary
Itch is defined as an unpleasant sensation that evokes the desire to scratch. Chronic itch, defined as itch persisting for more that 6 weeks, is a key symptom in many diseases severely affects the quality of life of the affected patients and represents a substantial economic burden for the society. At present, there are no effective treatments for chronic itch diseases. Moreover, chronic itch patients express differences in their genes compared with people who do not suffer from itch. With this experiment, we wish to analyse differences in genes expression in healthy volunteers who have been exposed to artificial itch from small plant needles from the plant cowhage (mucuna pruriens) and compare them to controls who have not been exposed to itch.
Official title: Identification of the Mechanism of Non-histaminergic Itch Probing Epigenetic Changes Following Cowhage Application
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-05-15
Completion Date
2027-12-31
Last Updated
2025-06-04
Healthy Volunteers
Yes
Conditions
Interventions
blood sampling
Whole blood samples (5 mL per each time point, a total of 20 mL per subject) will be collected
Locations (1)
Aalborg University
Gistrup, Denmark