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RECRUITING
NCT06998004
PHASE1

A Trial to Evaluate the Safety and Immunogenicity of an Investigational Vaccine for the Prevention of Yellow Fever, and of an Investigational Vaccine for the Prevention of Rabies, in Healthy Adults

Sponsor: AstriVax Therapeutics

View on ClinicalTrials.gov

Summary

The purpose of this first time in humans trial is to evaluate the safety, reactogenicity and immunogenicity of AVX70120 and of AVX70481 in healthy participants.

Official title: A Phase I, Randomized, Double-blind, Multi-centre, Placebo-controlled, Dose-escalation Study to Evaluate the Safety, Reactogenicity and Immunogenicity of AstriVax' Investigational Vaccine for the Prevention of Yellow Fever (AVX70120), and of AstriVax' Investigational Vaccine for the Prevention of Rabies (AVX70481), in Healthy Adults Aged 18 to 40 Years

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

144

Start Date

2024-06-16

Completion Date

2026-03-31

Last Updated

2025-05-31

Healthy Volunteers

Yes

Interventions

BIOLOGICAL

AVX70120 low dose level

Low dose level of AVX70120, AstriVax' investigational vaccine for the prevention of yellow fever

BIOLOGICAL

AVX70120 middle dose level

Middle dose level of AVX70120, AstriVax' investigational vaccine for the prevention of yellow fever

BIOLOGICAL

AVX70120 high dose level

High dose level of AVX70120, AstriVax' investigational vaccine for the prevention of yellow fever

BIOLOGICAL

AVX70481 low dose level

Low dose level of AVX70481, AstriVax' investigational vaccine for the prevention of rabies

BIOLOGICAL

AVX70481 middle dose level

Middle dose level of AVX70481, AstriVax' investigational vaccine for the prevention of rabies

BIOLOGICAL

AVX70481 high dose level

High dose level of AVX70481, AstriVax' investigational vaccine for the prevention of rabies

OTHER

Placebo

Placebo

Locations (2)

Centre for the Evaluation of Vaccination (CEV)

Antwerp, Belgium

University Hospital Ghent - Centrum voor Vaccinologie (CEVAC)

Ghent, Belgium