Clinical Research Directory

Inclusion Criteria: * 18-65 years old (including borderline values). * Elective surgical patients under local anaesthesia for operation of AVF * Voluntary participation in this study and signing of informed consent. * American Society of Anesthesiologists (ASA) classification \< Grade IV. * BMI range: 18-28kg/m2 (including borderline values). Exclusion Criteria: * hypersensitivity to remimazolam or benzodiazepines. * patients with severe cardiac, pulmonary, neurological diseases or liver failure. -- Preoperative use of sedative drugs, anticonvulsants, etc. * patients who cannot cooperate with postoperative recovery or follow-up. * vulnerable groups, including those with mental illness, cognitive impairment, critically ill patients, pregnant women, illiterates, etc.