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Minimally Invasive Protocols for the Treatment and Control of Caries Lesions in Children and Adolescents
Sponsor: University of Nove de Julho
Summary
This multicenter longitudinal interventional study aims to evaluate the effectiveness of four minimally invasive protocols for the prevention and control of dental caries in children and adolescents. In the first phase, approximately 50,000 children aged 6 to 12 years from five Brazilian cities will undergo dental screening and receive preventive oral health interventions. In the second phase, 2,500 children diagnosed with active caries will be treated with different interventions, depending on lesion severity. All participants will be followed up every three months for 24 months.
Official title: Minimally Invasive Protocols for the Treatment and Control of Caries Lesions in Children and Adolescents:A Multicenter Longitudinal Interventional Study
Key Details
Gender
All
Age Range
6 Years - 12 Years
Study Type
INTERVENTIONAL
Enrollment
2500
Start Date
2026-02
Completion Date
2027-12
Last Updated
2026-01-27
Healthy Volunteers
Yes
Conditions
Interventions
Fluoride Varnish Application (Preventive Protocol)
Single application of Duraphat® fluoride varnish on permanent molars and incisors, repeated every 3 months.
Fluoride Varnish for Active Enamel Lesions
Weekly fluoride varnish applications for 4 weeks, followed by quarterly maintenance applications.
Atraumatic Restorative Treatment (ART) Sealant
Sealant placement with high-viscosity glass ionomer using the ART technique, with quarterly fluoride varnish.
Atraumatic Restorative Treatment (ART)
Manual caries removal and cavity restoration with glass ionomer cement, followed by fluoride varnish every 3 months.