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Quadriceps Motor Unit Adaptation to Simulated Knee Injury
Sponsor: University of Central Florida
Summary
This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.
Key Details
Gender
All
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2026-08-01
Completion Date
2027-08-01
Last Updated
2026-05-01
Healthy Volunteers
Yes
Conditions
Interventions
Joint Effusion via 60 mL Sterile Saline
Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.
Intra-articular Lidocaine
Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.
Sham injection
Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.
Locations (1)
University of Central Florida
Orlando, Florida, United States