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Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
Sponsor: Centre Hospitalier Universitaire de la Guadeloupe
Summary
Dengue virus (DENV) belongs to the genus of Flavivirus transmitted by the mosquito Aedes aegypti and is responsible for an infectious disease associated with different forms and severities such as dengue hemorrhagic fever or shock syndrome. Several recent reports have shown that sickle cell patients exhibited an increased risk of developing severe forms of dengue episodes compared to non-sickle cell subjects. Furthermore, among major sickle cell syndromes, these studies suggest that SC patients are at the highest risk of death during these infectious episodes although this sickle cell syndrome is generally associated with a more moderate expression of sickle cell disease. However, the mechanisms involved remain unknown to date. The aim of the present study is to identify the molecular and cellular basis of this increased severity of dengue in SC patients. We hypothesize an exacerbation during DENV infection of the inflammatory response in SC patients compared to SS patients.
Key Details
Gender
All
Age Range
6 Years - 25 Years
Study Type
OBSERVATIONAL
Enrollment
130
Start Date
2024-06-24
Completion Date
2026-06-24
Last Updated
2025-06-03
Healthy Volunteers
Yes
Locations (1)
Chu de La Guadeloupe
Pointe-à-Pitre, Guadeloupe