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Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
Sponsor: Kardigan, Inc.
Summary
The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.
Official title: A Phase 2b/3, Randomized, Double-Blinded, Placebo Controlled Study ChecKing the Efficacy and Safety of ATAciguat to Slow the Progression of VaLvular DYsfunction in Participants With Moderate Calcific Aortic Valve STenosis
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1276
Start Date
2025-06-27
Completion Date
2030-09-30
Last Updated
2026-05-06
Healthy Volunteers
No
Conditions
Interventions
Ataciguat
Ataciguat will be administrated daily for up to 156 weeks
Placebo
Placebo will be administrated daily for up to 156 weeks
Locations (70)
University of Alabama at Birmingham (UAB) - Medical Center
Birmingham, Alabama, United States
Heart Center Research LLC
Huntsville, Alabama, United States
Onyx Clinical Research - Peoria
Peoria, Arizona, United States
Mayo Clinic - Phoenix
Phoenix, Arizona, United States
National Heart Institute
Beverly Hills, California, United States
UCLA Ronald Reagan Medical Center
Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
Profound Research LLC at Southern California Heart Specialists
Pasadena, California, United States
University of California, San Francisco (UCSF) - Medical Center
San Francisco, California, United States
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
Torrance, California, United States
HCA Florida - JFK Hospital
Atlantis, Florida, United States
New Generation of Medical Research
Hialeah, Florida, United States
Memorial Healthcare System
Hollywood, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
University of Miami
Miami, Florida, United States
New Generation of Medical Research - Naples
Naples, Florida, United States
Flourish Research - St. Augustine
Saint Augustine, Florida, United States
Sarasota Memorial Hospital
Sarasota, Florida, United States
University of South Florida
Tampa, Florida, United States
Wellstar Kennestone Hospital
Marietta, Georgia, United States
Northwestern University The Feinberg School of Medicine
Chicago, Illinois, United States
Ascension Heart and Vascular/Alexian Brothers Heart & Vascular Institute
Elk Grove Village, Illinois, United States
NorthShore University Health System
Glenview, Illinois, United States
Riverside Medical Center - Illinois
Kankakee, Illinois, United States
Midwest Cardiovascular Institute
Naperville, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Midwest Cardiovascular Research and Education Foundation
Elkhart, Indiana, United States
University of Louisville Health
Louisville, Kentucky, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Corewell Health
Royal Oak, Michigan, United States
Henry Ford Hospital
West Bloomfield, Michigan, United States
M Health Fairview St. John's Hospital
Maplewood, Minnesota, United States
Mayo Clinic - Rochester
Rochester, Minnesota, United States
Washington University
St Louis, Missouri, United States
Deborah Heart and Lung Center
Browns Mills, New Jersey, United States
Virtua Our Lady of Lourdes Hospital
Camden, New Jersey, United States
Atlantic Health System - Morristown Medical Center
Morristown, New Jersey, United States
Inspira Medical Centers
Mullica Hill, New Jersey, United States
Inspira Medical Center of Vineland
Vineland, New Jersey, United States
Albany Medical Center
Albany, New York, United States
University of Buffalo
Buffalo, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
Duke University School of Medicine
Durham, North Carolina, United States
Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health
Greensboro, North Carolina, United States
Sanford Fargo
Fargo, North Dakota, United States
The Lindner Center for Research and Education at The Christ Hospital
Cincinnati, Ohio, United States
Bethesda North Hospital, TriHealth, Inc
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
ProMedica Toledo Hospital
Toledo, Ohio, United States
Ascension St. John Hospital
Tulsa, Oklahoma, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
OnSite Clinical Solutions, LLC - Rock Hill
Rock Hill, South Carolina, United States
TriStar Centennial Medical Center
Nashville, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
St. David's Heart and Vascular dba Austin Heart - Main Office
Austin, Texas, United States
Methodist Dallas Medical Center
Dallas, Texas, United States
Houston Methodist Hospital
Houston, Texas, United States
University of Texas Medical Branch - Galveston
Houston, Texas, United States
Baylor Scott and White - The Heart Hospital Baylor Plano
Plano, Texas, United States
Methodist Hospital - San Antonio
San Antonio, Texas, United States
Houston Methodist Sugar Land Hospital
Sugar Land, Texas, United States
University of Utah Hospital & Clinics
Salt Lake City, Utah, United States
St. Boniface Hospital
Winnipeg, Mantioba, Canada
Montreal Heart Institute - Institut de Cardiologie de Montreal
Montreal, Quebec, Canada
Centre Hospitalier de l Universite de Montreal (CHUM)
Montreal, Quebec, Canada
Institut Universitaire de Cardiologie et de Pneumologie De Quebec
Québec, Quebec, Canada