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Comparison of Two Protocols in Frozen Embryo Transfer
Sponsor: Malihe Mahmoudinia
Summary
This randomized clinical trial evaluates two different endometrial preparation protocols-hormone replacement therapy (HRT) and natural cycle-for frozen embryo transfer (FET) in infertile women undergoing assisted reproductive technology (ART). The goal is to compare implantation, clinical pregnancy, and ongoing pregnancy outcomes.
Official title: Comparison of the Pregnancy Outcomes of Frozen Embryo Transfer in the Natural Cycle vs. Artificial Cycle
Key Details
Gender
FEMALE
Age Range
18 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
112
Start Date
2025-07-05
Completion Date
2026-07-05
Last Updated
2025-06-04
Healthy Volunteers
Yes
Conditions
Interventions
hormone replacement therapy (HRT) group
Estradiol valerate is initiated at 4 mg/day on day 2 of the menstrual cycle and is adjusted to 8 mg/day based on endometrial thickness. Once the endometrial thickness reaches ≥8 mm, progesterone supplementation is started (400 mg vaginal suppositories twice daily and 50 mg intramuscular injections daily) for 5 days before blastocyst transfer.