Inclusion Criteria:
* Voluntary participation in this study and provision of a signed and dated written informed consent form before any study-specific procedures, sampling or analysis are conducted;
* Age range: 18 to 70 years old (inclusive), gender unrestricted
* Confirmed diagnosis of primary peritoneal tumors (including primary peritoneal carcinoma and malignant peritoneal mesothelioma) by cytological and/or histological methods, supported by complete pathological report documentation, with failure of first-line standard therapy.
* Patients with secondary peritoneal tumors confirmed by cytological and/or histological diagnosis (e.g., secondary to adenocarcinomas of gastric, colorectal, platinum-resistant advanced ovarian, or fallopian tube origin) who meet the following criteria: Treatment Failure: Progression after ≥2 prior lines of standard therapy; Lack of Standard Options: No available standard treatment, and/or Intolerance to Standard Therapy: Defined as: Grade ≥3 adverse events (AEs) related to prior therapy, or Persistent/recurrent AEs below grade 3 that preclude further treatment (as judged by the investigator).
\*：Patients with pseudomyxoma peritonei (PMP) of ovarian or appendiceal origin will be excluded from this study.
* Contrast-enhanced CT/MRI demonstrating intra-abdominal space-occupying lesions with at least one evaluable target lesion (per iRECIST criteria);
* Prior to enrollment, systemic anti-tumor therapies must meet the following washout period requirements:
1. Nitrosoureas and mitomycin C: ≥6 weeks;
2. Other chemotherapeutic agents and small-molecule targeted agents: ≥3 weeks or • half-lives (including active metabolites), whichever is longer;
3. Biological agents (such as immune checkpoint suppression), ≥4 weeks;
4. Biologics (e.g., immune checkpoint inhibitors): ≥4 weeks
* Subjects must meet \*\*one\*\* of the following criteria: Willing to provide either: FFPE tissue blocks or 8 consecutive unstained slides from the most recent pathological specimen, or Ascites tumor cells (for cytological analysis), with B7-H3 positivity confirmed in the tumor tissue/ascites; OR Documented B7-H3 positivity in archival tumor tissue (e.g., from prior immunohistochemistry or RNA-seq reports).
* No intraperitoneal drug injections (including hyperthermic intraperitoneal chemotherapy, HIPEC) have been administered within 1 month prior to signing the informed consent form, except for diagnostic paracentesis.;
* Life expectancy ≥3 months;
* Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0-2;
* Laboratory tests during the screening period must meet the following criteria (no blood transfusion, G-CSF use, or medication to correct values within 14 days prior to hematological testing) :
* Blood routine (within 7 days) :
* White Blood Cells (WBC) ≥3.0×10⁹/L;
* Absolute Neutrophil Count (ANC) ≥1.5×10⁹/L;
* Lymphocytes ≥0.8×10⁹/L;
* Platelets (PLT) ≥90×10⁹/L;
* Hemoglobin (HGB)≥90 g/L (\*transfusion and erythropoietin use are permitted\*); If active bleeding or other ongoing conditions (e.g., hemolysis, bone marrow infiltration) lead to increased red blood cell destruction/impaired production, requiring repeated transfusions or erythrocyte therapies, the patient's eligibility must be discussed with the \*\*sponsor\*\* based on clinical context prior to enrollment.
* Liver function (within 7 days) :
* Total Bilirubin (TBIL) ≤1.5× upper limit of normal (ULN);
* ALT/AST≤2.5× ULN;
* Kidney function (within 7 days) :
* Serum Creatinine (Cr)≤1.5× ULN or Creatinine Clearance (CrCl) ≥30 mL/min (calculated by Cockcroft-Gault formula) Cockcroft-Gault formula);
* Coagulation function (within 7 days) :
* International Normalized Ratio (INR) or Prothrombin Time (PT)≤1.5× ULN;
* Activated Partial Thromboplastin Time (APTT) ≤1.5× ULN;
* Toxicities from prior systemic therapy must have recovered to≤ Grade 1 or baseline levels prior to the first dose (except for alopecia);
* Males of reproductive potential and females of childbearing potential must agree to use highly effective contraception from the time of signing the informed consent form until 180 days after the last dose of MT027 Cell Infusion. Females of childbearing potential include: Premenopausal women .Women within 2 years postmenopausal.
Exclusion Criteria:
* Known hypersensitivity to the investigational product or its excipients;
* Other malignancies within 5 years (except cured carcinoma in situ of cervix/breast/prostate/thyroid/skin \[basal cell/squamous cell carcinoma\]);
* Contraindications to peritoneal puncture or investigator-determined unsuitability for intraperitoneal therapy;
* MSI-H (microsatellite instability-high)/dMMR (mismatch repair deficient) colorectal cancer patients without prior immunotherapy;
* Portal vein thrombosis confirmed by imaging;
* Bowel obstruction within 4 weeks prior to dosing;
* Peritoneal adhesions/jelly-like ascites (e.g., pseudomyxoma peritonei) limiting drug diffusion;
* Major surgery (except intraperitoneal port placement) or abdominal radiotherapy within 4 weeks before first dose;
* High-dose systemic corticosteroids (prednisone ≥20 mg/day) for \>14 days within 4 weeks prior to treatment (topical/inhaled steroids allowed);
* Participation in other clinical trials within 4 weeks prior to screening;
* Prior therapy targeting same pathway (antibody/ADC/cell therapy);
* Severe autoimmune diseases (e.g., lupus, rheumatoid arthritis);
* Recipients of allogeneic tissue/organ transplants;
* Live vaccination within 4 weeks before cell therapy or planned during study;
* Active infections: HBV (HBsAg+ with detectable DNA)、 HCV (Ab+ except RNA-undetectable) 、 HIV+ 、Syphilis (TPPA+) 、Active EBV/CMV infection;
* Active systemic infections, coagulopathy, or other significant comorbidities;
* Organ dysfunction: Cardiac: NYHA Class ≥III ；Hepatic: Child-Pugh C； Renal: CKD Stage ≥4 ；Pulmonary: Severe respiratory failure;
* Pregnancy/Lactation;
* Investigator-determined unsuitability based on clinical/laboratory findings.
