Clinical Research Directory

ASD group： Inclusion Criteria: 1. Children diagnosed with ASD according to a clinical judgement based on the criteria of ASD in DSM-5 and further confirmed with ADOS-2; 2. Ages 1.5-2.5 years; 3. Parents/caregivers understand the content of the study and agree to participate in. GDD group： Inclusion Criteria: 1. Age 1.5-2.5 years, gestational age 37-42 weeks, birth weight 2500-4000g; 2. Clinically diagnosed with GDD (Global Developmental Delay) according to the DSM-V diagnostic criteria, with a Griffiths Development Scales-Chinese edition(GDS-C) assessment showing a Developmental Quotient (DQ) ≤75 in two or more domains; 3. Those who did not meet the initial screening positivity criteria for ASD (Autism Spectrum Disorder) using M-CHAT-R/F. LD group： Inclusion Criteria: 1. Age 1.5-2.5 years, gestational age 37-42 weeks, birth weight 2500-4000 g; 2. Clinically diagnosed with LD (Language Disorder) according to the DSM-V diagnostic criteria, with a Developmental Quotient (DQ) ≤75 in the language domain of the Griffiths Development Scales-Chinese edition(GDS-C) and DQ \>75 in all other domains; 3. Those who did not meet the initial screening positivity criteria for ASD (Autism Spectrum Disorder) assessed by M-CHAT-R/F Exclusion Criteria for ASD, GDD, and LD groups: 1. Rett Syndrome, Fragile X Syndrome, Angelman Syndrome, Prader-Willi Syndrome, tuberous sclerosis, and other syndromes caused by known genetic defects or inherited metabolic diseases; 2. Children with brain injuries, specific chronic or congenital diseases. 3. The gestational age is less than 37 weeks, or the birth weight is lower than 2500g. TD group： Inclusion Criteria: 1. Healthy, typically developing toddlers aged 1.5-2.5 years ; 2. gestational age of 37-42 weeks, birth weight of 2500-4000 g; 3. Developmental Quotients(DQs) are greater than 75 in all domains of theGriffiths Development Scales-Chinese edition(GDS-C); 4. Screened negative by M-CHAT-R/F screening for autism spectrum disorder (ASD). Exclusion Criteria: Children with neurodevelopmental disorders (e.g., developmental delay, language impairment), neurological conditions (e.g., epilepsy, tuberous sclerosis), or other severe chronic diseases were excluded.