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Bile Omics for Diagnosing Indeterminate Biliary Strictures
Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Summary
The diagnosis of malignant biliary strictures remains a challenging aspect of biliary endoscopy. Molecular biological testing techniques based on bile have been reported to improve detection rates. However, whether the combination of bile-based omics studies and biliary brush cytology/biopsy can enhance diagnostic sensitivity has not yet been reported. This study aims to collect bile from patients with malignant biliary strictures, screen for molecular markers associated with biliary malignancies through multi-omics analysis, and subsequently validate these markers to establish a bile-based molecular diagnostic model.
Official title: The Diagnostic Value of Bile-based Omics Analysis for Indeterminate Biliary Strictures
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
260
Start Date
2024-01-01
Completion Date
2026-12-31
Last Updated
2025-06-11
Healthy Volunteers
No
Conditions
Interventions
Endoscopic retrograde cholangiopancreatography
Since patients with biliary strictures almost universally require endoscopic biliary interventions for both diagnostic and drainage purposes, bile aspiration can be readily obtained during these procedures, facilitating subsequent analyses. However, proteomic and metabolomic profiling of bile in malignant biliary strictures remains unreported to date. This study aims to evaluate the diagnostic value of combining bile proteomics/metabolomics with biliary brush cytology/biopsy for malignant biliary strictures, while also providing evidence for identifying potential biomarkers.
Locations (1)
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, China