Clinical Research Directory

Inclusion Criteria: 1. \- Informed Consent Voluntarily signed informed consent after full understanding of the study, with commitment to comply with all protocol requirements and assessment schedules. 2. Age 18-75 years inclusive. 3. Diagnosis Histologically/cytologically confirmed hepatocellular carcinoma (HCC) OR clinically diagnosed HCC per 2024 Chinese Guidelines for Primary Liver Cancer. 4. Tumor Status Meets ONE of the following: Multifocal tumors (2-4 lesions) Single lesion \>5 cm in longest diameter Stage IIIa HCC with Vp1/Vp2/Vp3 portal vein tumor thrombus 5. Resectability Technically amenable to curative resection per surgeon assessment. 6. Liver Function Child-Pugh class A. 7. Performance Status ECOG PS 0-1. 8. Prior Therapy No previous systemic treatment for HCC. 9. Measurable Disease ≥1 radiologically measurable lesion per mRECIST. 10. Organ Function (1) Hematological: ANC ≥1.5×10⁹/L Hemoglobin ≥90 g/L Platelets ≥50×10⁹/L (2) Hepatic: Total bilirubin ≤1.5×ULN AST/ALT ≤2.5×ULN Albumin ≥28 g/L (3) Coagulation: INR ≤2.3 OR PT prolongation ≤3 sec vs control (4) Renal: eGFR \>90 mL/min/1.73m² (CKD-EPI) 11. Contraception Women of childbearing potential: Negative serum pregnancy test within 7 days prior to enrollment. All subjects: Use highly effective contraception during treatment and for 180 days post-last dose. Exclusion Criteria: 1. Pregnancy/Lactation Women who are pregnant or breastfeeding. 2. Concurrent Malignancy History of other malignancies within 5 years except: 3. Curatively treated basal cell carcinoma Cervical carcinoma in situ Papillary thyroid carcinoma 4. Drug Hypersensitivity Known allergy to finolizumab, bevacizumab, or their excipients. Bleeding Risk History of upper GI bleeding OR active hemorrhagic disorders. 5. Uncontrolled Cardiac Disease Clinically significant cardiac conditions including: NYHA Class II+ heart failure Unstable angina Myocardial infarction within 1 year Clinically significant arrhythmias requiring intervention 6. Autoimmune Disorders Active autoimmune diseases or history of autoimmune disorders. 7. Immunodeficiency Immunodeficiency conditions including: HIV positive status Primary/secondary immunodeficiency History of organ/bone marrow transplantation 8. Psychiatric Conditions Severe psychiatric disorders OR substance abuse involving psychotropic drugs. 9. Uncontrolled Comorbidities Severe uncontrolled recurrent infections OR other significant uncontrolled comorbidities. 10. Investigator Discretion Any condition deemed ineligible by the investigator.