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Brain Stimulation to the Hippocampus in Schizophrenia
Sponsor: Stanford University
Summary
Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatments have significant side effect burden and are often ineffective. Disordered neural activity in the hippocampus likely contributes to schizophrenia symptoms, but to develop better therapies we need to understand whether hippocampal activity in schizophrenia can be systematically affected by non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS). This proposal will investigate the use of connectivity-guided theta burst brain stimulation to specifically target hippocampal function in schizophrenia, offering insights into fundamental hippocampal processes, schizophrenia pathophysiology, and potential avenues to use brain stimulation as a therapeutic tool in this devastating illness.
Official title: Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-10-01
Completion Date
2027-09-30
Last Updated
2026-02-27
Healthy Volunteers
Yes
Interventions
Intracranial electrodes
Intracranial electrodes will be used for the delivery of invasive electrical brain stimulation.
TMS
TMS will be used for the delivery of noninvasive brain stimulation
TMS sham
Sham TMS will be used as a comparator for noninvasive brain stimulation
Locations (1)
Stanford University
Stanford, California, United States