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RECRUITING
NCT07010614
NA

Brain Stimulation to the Hippocampus in Schizophrenia

Sponsor: Stanford University

View on ClinicalTrials.gov

Summary

Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatments have significant side effect burden and are often ineffective. Disordered neural activity in the hippocampus likely contributes to schizophrenia symptoms, but to develop better therapies we need to understand whether hippocampal activity in schizophrenia can be systematically affected by non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS). This proposal will investigate the use of connectivity-guided theta burst brain stimulation to specifically target hippocampal function in schizophrenia, offering insights into fundamental hippocampal processes, schizophrenia pathophysiology, and potential avenues to use brain stimulation as a therapeutic tool in this devastating illness.

Official title: Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2025-10-01

Completion Date

2027-09-30

Last Updated

2026-02-27

Healthy Volunteers

Yes

Interventions

DEVICE

Intracranial electrodes

Intracranial electrodes will be used for the delivery of invasive electrical brain stimulation.

DEVICE

TMS

TMS will be used for the delivery of noninvasive brain stimulation

DEVICE

TMS sham

Sham TMS will be used as a comparator for noninvasive brain stimulation

Locations (1)

Stanford University

Stanford, California, United States