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Timing of Aminophylline and Recovery in Pediatric Ambulatory Surgery
Sponsor: Hany Mohammed El-Hadi Shoukat Mohammed
Summary
Beyond its established use as a bronchodilator and therapy for apnea of prematurity, aminophylline has demonstrated utility in reversing the effects of anesthetics, enhancing recovery by accelerating respiratory and cognitive functions. Variations in dosage (1-6 mg/kg) have been explored, but questions persist regarding optimal timing and dosing for pediatric surgical populations to achieve maximal efficacy with minimal adverse effects. This randomized controlled study aims to evaluate the effect of early versus late aminophylline administration on recovery profiles in pediatric patients undergoing ambulatory surgery under sevoflurane anesthesia. Sixty children aged 4-12 years will be randomly allocated into three groups: Group (E) will receive aminophylline early intraoperatively, Group (L) will receive aminophylline late intraoperatively, and Group (C) will receive normal saline post-anesthetic discontinuation.
Official title: Effect of Early Versus Late Aminophylline Administration on Recovery Profile in Pediatric Patients Undergoing Ambulatory Surgery Under General Anesthesia; a Randomised Controlled Trial
Key Details
Gender
All
Age Range
4 Years - 12 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-06-15
Completion Date
2025-08-15
Last Updated
2025-06-08
Healthy Volunteers
No
Interventions
Group (E): receive aminophylline early intraoperatively,
Group E (n=20): patients received aminophylline at an early intraoperative time immediately after fixation of ETT and confirmation of bilateral adequate lung ventilation (EtSevo\< 1)
Group (L) received aminophylline late intraoperatively
Group L (n=20): patients received aminophylline at late intraoperative time immediately after discontinuation of sevoflurane (EtSevo \< 1).
Group (C) will receive normal saline post-anesthetic discontinuation.
Group (C) (n=20): patients received normal saline immediately after discontinuation of sevoflurane (EtSevo \< 1).