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Dynamic Treatment Regimes for Opioid Use Disorder
Sponsor: Brigham and Women's Hospital
Summary
This study aims to develop and evaluate dynamic treatment regimes (DTRs) to improve personalized care for individuals with opioid use disorder (OUD). Using machine learning methods and longitudinal data from a national behavioral health provider, the investigators will identify optimal treatment sequences that minimize the risk of overdose and improve recovery outcomes. A pilot hybrid factorial SMART trial will be conducted to assess the feasibility and acceptability of implementing these personalized treatment decision rules in real-world clinical settings.
Official title: Dynamic Treatment Regimes for Personalized Opioid Use Disorder Care
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2028-07-01
Completion Date
2030-06-01
Last Updated
2025-11-04
Healthy Volunteers
No
Conditions
Interventions
Medication for opioid use disorder
A medication treatment component delivered in Week 1 as part of a 2×2 factorial SMART design. The exact content (e.g., treatment modality or intensity) will be finalized based on model results from Aim 1, which identifies optimal dynamic treatment regimes.
psychotherapy
A behavioral treatment component delivered in Week 1 as part of a 2×2 factorial SMART design. The exact content (e.g., treatment modality or intensity) will be finalized based on model results from Aim 1, which identifies optimal dynamic treatment regimes.
Locations (1)
Discovery Behavioral Health
Irvine, California, United States