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Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children
Sponsor: Mansoura University
Summary
The study aims at reversing pupillary dilatation. and cycloplegia in children undergoing cycloplegic refraction for eyeglasses prescription and ocular examination. This will be achieved using pilocarpine , phentolamine or a combination. This may help decrease the glare and improve near vision early to decrease unwanted effects of cycloplegic drops.
Key Details
Gender
All
Age Range
5 Years - 12 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-06-01
Completion Date
2025-12-30
Last Updated
2025-06-10
Healthy Volunteers
No
Conditions
Interventions
Use of phentolamine eye drops to reverse cycloplegia
Use of phentolamine 0.75% eye drops to reverse cycloplegia
Pilocarpine 0.1%
Use of pilocarpine 0.1% to reverse cycloplegia
Combination of pilocarpine 0.1% and phentolamine 0.75%
Combination of pilocarpine 0.1% and phentolamine 0.75%