Clinical Research Directory

Inclusion Criteria: * Over 18 years old and under 85 years old; * Presence of a solid lesion greater than 1 cm in diameter, as identified by cross-sectional imaging (Magnetic Resonance Imaging, Computed Tomography or abdominal ultrasound), located in anatomical regions accessible via endoscopic ultrasound (EUS)-including but not limited to the pancreas, retroperitoneum, liver, mediastinum, or subepithelial layers of the gastrointestinal tract-where tissue acquisition is clinically indicated to establish a definitive histopathological diagnosis.; * Must be able to receive examinations in the research center; * Must be able to sign the informed consent. Exclusion Criteria: * Hemoglobin ≤8.0 g/dL; * Pregnant women; * Coagulation disorders(Platelet \<50,000/mm3, International Normalized Ratio \> 1.5); * Took anticoagulants such as aspirin, warfarin in the latest week; * Acute pancreatitis in the past two weeks; * inability to safely perform Endoscopic Ultrasound-Guided Tissue Acquisition (eg, cardiorespiratory dysfunction, mental diseases, or drug addiction); refusal or inability to provide an informed consent.