Clinical Research Directory

Inclusion Criteria \* : * Persons aged over 50 and under 75 (74 years of age or older). * Active smokers or former smokers who quit less than 15 years ago. * Persons whose consumption is estimated at 20 packs/year or more, down to ≥15 cigarettes/day for a duration of consumption of ≥25 years and up to ≥10 cigarettes/day for ≥30 years, which takes into account the predominance of duration of consumption over quantity consumed in the risk of lung cancer. A pack-year corresponds to the consumption of one pack of 20 manufactured cigarettes per day for one year. A multiplier coefficient will be taken into account depending on the mode of consumption: Rolled cigarettes: 2; Cigarillos: 3; Cigars: 4; Pipes: 2.5; Hookahs: 25. * Persons affiliated with social security. - Person having signed their consent to participate in the study after having received full information about it, including the risks associated with participation. * Exclusion Criteria \* : * Individuals with severe comorbidities contraindicating lung cancer investigations and/or treatment (including surgery or stereotactic radiotherapy); * Individuals with impaired general condition (PS 2 and above); * Individuals with dyspnea at rest (mMRC4); * Individuals with a history of cancer undergoing active surveillance by chest computed tomography (CT or PET scan); personal history of lung cancer (lifetime); * Individuals with symptoms suggestive of lung cancer (hemoptysis, unexplained weight loss, recent onset or change in respiratory symptoms, etc.); * Individuals refusing to participate in the study * Individuals withdrawing their consent.