Clinical Research Directory

Inclusion Criteria as defined in the TTM trial (NCT01020916): * Age ≥ 18 years old * Out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause * Return of spontaneous circulation (ROSC) * Unconsciousness (Glasgow Coma Score \< 8) (patients not able to obey verbal commands) after sustained ROSC Exclusion Criteria as defined in the TTM trial (NCT01020916): * In-hospital cardiac arrest * OHCA of presumed non-cardiac cause, e.g. after trauma or dissection/rupture of major artery OR Cardiac arrest caused by initial hypoxia (i.e. drowning, suffocation, hanging). * Known bleeding diathesis (medically induced coagulopathy (e.g warfarin, clopidogrel) does not exclude the patient). * Suspected or confirmed acute intracranial bleeding * Suspected or confirmed acute stroke * Unwitnessed asystole * Known limitations in therapy and Do Not Resuscitate-order * Known disease making 180 days survival unlikely * Known pre-arrest CPC 3 or 4 * Temperature \< 30°C on admission * \> 4 hours (240 minutes) from ROSC to screening * Systolic blood pressure \< 80 mm Hg in spite of fluid loading/vasopressor and/or inotropic medication/intra aortic balloon pump. If the systolic blood pressure (SBP) is recovering during the inclusion window (220 minutes) the patient can be included.