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Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
Sponsor: The Florey Institute of Neuroscience and Mental Health
Summary
The Investigators are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke. The goal is to test how practical it is to carry out a detailed health assessment process-called "deep phenotyping"-with this group. This process involves collecting a wide range of information and samples from stroke survivors to better understand each participant's condition. The Investigators will look at how well this approach works in practice, including how easy it is to use, whether it's done consistently, and how acceptable it is to participants. At the same time, the Investigators will also explore how different factors-such as biological markers (biomarkers), age, sex, type of stroke, lifestyle, and environment-might be related to stroke recovery. This pilot study will prepare for larger studies in the future.
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-07-19
Completion Date
2027-12
Last Updated
2026-04-21
Healthy Volunteers
No
Interventions
Observational Cohort
The deep phenotyping observational study observes young adult stroke recovery trajectories and will also explore potential recovery biomarkers via: advanced MRI imaging; samples including blood, saliva, urine and hair stored for future analysis that may include (but is not limited to) proteomics, genomics and cortisol; and, a PET scan sub study involving \~20 participants (additional inclusion criteria) exploring the association of reactive astrogliosis with recovery outcomes using the experimental Positron Emission Tomography 18F-SMBT-1 tracer (AU TGA CTN in place). Associations with personal and environmental factors including: physical activity and sleep quality via device (Actigraph and Somfit) and self-report; exposures such as home and work environments, diet, socioeconomic status, and dental health; quality of life, resilience, and locus of control. Monitor healthcare utilisation, changes in medication and medical condition, participant experience and response to the assessments.
Locations (2)
Austin Health
Heidelberg, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre
Heidelberg, Victoria, Australia